Pyodermatitis-pyostomatitis vegetans (PPV) constitutes an inflammatory mucocutaneous dermatosis that is associated with inflammatory bowel disease. Clinically, PPV appears as pustules on mucosal surfaces and as vegetating exudative plaques on intertriginous surfaces. It is typically a clinical diagnosis supported by histological findings. Microscopic findings include epidermal hyperplasia, focal acantholysis, and a dense mixed inflammatory infiltrate with intraepithelial and subepithelial eosinophilic microabscesses. In the recent literature, immunofluorescence has been thought to be negative in PPV or, if positive, an aberrant finding. Herein, we report 2 cases of PPV associated with inflammatory bowel disease, which display intercellular IgA deposits. Although these cases may represent isolated epiphenomena, it is possible that the paucity of PPV cases with immunofluorescent studies hitherto has led to an oversight of an interesting association between intercellular IgA and PPV.

译文

:脓皮炎-化脓性植物炎(PPV)构成了与炎症性肠病有关的炎症性粘膜皮肤性皮肤病。临床上,PPV在粘膜表面以脓疱的形式出现,在三叉间表面以植物性渗出性斑块出现。通常是组织学检查结果支持的临床诊断。显微镜下的发现包括表皮增生,局灶性棘层松解以及上皮内和上皮下嗜酸性微脓肿的致密混合炎性浸润。在最近的文献中,免疫荧光在PPV中被认为是阴性的,或者,如果阳性,则是异常的发现。在此,我们报告了2例与炎症性肠病相关的PPV病例,这些病例表现出细胞间IgA沉积物。尽管这些病例可能代表了孤立的现象,但迄今为止对PPV病例进行免疫荧光研究的可能性很低,导致对细胞间IgA与PPV之间有趣关系的疏忽。

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