Realistic HIV models tend to be rather complex and many recent models proposed in the literature could not yet be analyzed by traditional identifiability testing techniques. In this paper, we check a priori global identifiability of some of these nonlinear HIV models taken from the recent literature, by using a differential algebra algorithm based on previous work of the author. The algorithm is implemented in a software tool, called DAISY (Differential Algebra for Identifiability of SYstems), which has been recently released (DAISY is freely available on the web site http://www.dei.unipd.it/~pia/ ). The software can be used to automatically check global identifiability of (linear and) nonlinear models described by polynomial or rational differential equations, thus providing a general and reliable tool to test global identifiability of several HIV models proposed in the literature. It can be used by researchers with a minimum of mathematical background.

译文

:现实的HIV模型往往相当复杂,并且文献中提出的许多最新模型尚无法通过传统的可识别性测试技术进行分析。在本文中,我们使用基于作者先前工作的微分代数算法,对从最近文献中获得的某些非线性HIV模型进行先验全局可识别性。该算法在称为DAISY(用于系统识别的微分代数)的软件工具中实现,该工具最近已发布(DAISY可从网站http://www.dei.unipd.it/~pia/免费获得)。 。该软件可用于自动检查由多项式或有理微分方程描述的(线性和)非线性模型的全局可识别性,从而提供一种通用可靠的工具来测试文献中提出的几种HIV模型的全局可识别性。至少具有数学背景的研究人员可以使用它。

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