Reinioside C is a triterpene saponin from the the root of Polygala aureocauda Dunn (PAD). This study examined the effects of reinioside C on hyperlipidemic mice in vivo and endothelium cells, macrophages and smooth muscle cells in vitro. Mice were given a hyperlipidemic diet for 30 days, then administered reinioside C (4, 8, 16 mg/kg/day, p.o.) for 30 days. Then the serum lipid, superoxide dismutase (SOD), malonaldehyde (MDA), the total cholesterol (TC) and triglyceride (TG) in the liver extract were measured. Human umbilical vein endothelial (HUVECs), peritoneal macrophages and smooth muscle cells (SMCs) pre-treated with reinioside C were treated with oxidized low-density lipoprotein (OxLDL). The results showed that reinioside C decreased serum and liver tissue lipid profiles in hyperlipidemic mice. Moreover, reinioside C protected the HUVECs against the Ox-LDL induced LDH leakage and exerted a protective effect on oxidative lesions induced by OxLDL, inhibited cholesteryl ester accumulation in macrophages, and decreased [Ca2+](i) and SMC proliferation in vitro. Based on these results, it is suggested that reinioside C is a promising hypolipidemic candidate.

译文

:Reinioside C是从远志(Pogalgala aureocauda Dunn,PAD)的根中提取的三萜皂苷。这项研究检查了神经节苷脂C对体内高脂血症小鼠以及体外内皮细胞,巨噬细胞和平滑肌细胞的影响。给予小鼠高脂饮食30天,然后给予雷诺苷C(4、8、16 mg / kg / day,p.o。)30天。然后测量肝提取物中的血清脂质,超氧化物歧化酶(SOD),丙二醛(MDA),总胆固醇(TC)和甘油三酸酯(TG)。用氧化的低密度脂蛋白(OxLDL)处理了用皂苷C预处理的人脐静脉内皮细胞(HUVEC),腹膜巨噬细胞和平滑肌细胞(SMC)。结果表明,皂苷C降低了高脂血症小鼠的血清和肝组织脂质谱。此外,皂苷C保护HUVECs免受Ox-LDL诱导的LDH渗漏,并对OxLDL诱导的氧化损伤发挥保护作用,抑制巨噬细胞中胆固醇酯的积累,并降低[Ca2](i)和SMC的体外增殖。根据这些结果,提出了皂苷C是有希望的降血脂候选物。

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