The effects of the administration of 50 mg of guggulipid or placebo capsules twice daily for 24 weeks were compared as adjuncts to a fruit- and vegetable-enriched prudent diet in the management of 61 patients with hypercholesterolemia (31 in the guggulipid group and 30 in the placebo group) in a randomized, double-blind fashion. Guggulipid decreased the total cholesterol level by 11.7%, the low density lipoprotein cholesterol (LDL) by 12.5%, triglycerides by 12.0%, and the total cholesterol/high density lipoprotein (HDL) cholesterol ratio by 11.1% from the postdiet levels, whereas the levels were unchanged in the placebo group. The HDL cholesterol level showed no changes in the two groups. The lipid peroxides, indicating oxidative stress, declined 33.3% in the guggulipid group without any decrease in the placebo group. The compliance of patients was greater than 96%. The combined effect of diet and guggulipid at 36 weeks was as great as the reported lipid-lowering effect of modern drugs. After a washout period of another 12 weeks, changes in blood lipoproteins were reversed in the guggulipid group without such changes in the placebo group. Side effects of guggulipid were headache, mild nausea, eructation, and hiccup in a few patients.

译文

在61例高胆固醇血症患者中,将每日两次50毫克的Guggulipid或安慰剂胶囊的治疗效果与富含水果和蔬菜的谨慎饮食作为辅助治疗比较(Guggulipid组为31例,Guggulipid组为30例)。安慰剂组)以一种随机,双盲的方式。 Guggulipid使总胆固醇水平降低了11.7%,低密度脂蛋白胆固醇(LDL)降低了12.5%,甘油三酸酯降低了12.0%,总胆固醇/高密度脂蛋白(HDL)胆固醇的比例比饮食后降低了11.1%,而安慰剂组的水平没有变化。两组的高密度脂蛋白胆固醇水平无变化。指示氧化应激的脂质过氧化物在古格脂组中下降了33.3%,而安慰剂组没有任何下降。患者的依从性大于96%。在第36周时,饮食和含糖脂的联合作用与现代药物报道的降脂作用一样大。在又过了12周的冲洗期后,古吉脂组的血脂蛋白变化被逆转,而安慰剂组则没有这种变化。在少数患者中,古古柏脂的副作用是头痛,轻度的恶心,勃起和打ic。

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