Effect of coconut protein in rats fed high fat cholesterol containing diet on the metabolism of lipids and lipid peroxides was studied. In addition, effect of coconut protein were compared with rats fed L-arginine. The results indicate that those fed coconut protein and those fed L-arginine showed significantly lower levels of total cholesterol, LDL+ VLDL cholesterol, Triglycerides and Phospholipids in the serum and higher levels of serum HDL cholesterol. The concentration of total cholesterol, triglycerides and phospholipids in the tissues were lower in these groups. There was increased hepatic cholesterogenesis which is evident from the higher rate of incorporation of labeled acetate into free cholesterol. Increased conversion of cholesterol to bile acids and increased fecal excretion of bile acids were observed. Feeding coconut protein results in decreased levels of Malondialdehyde in the heart and increased activity of Superoxide dismutase and Catalase. Supplementation of coconut protein causes increased excretion of urinary nitrate which implies higher rate of conversion of arginine into nitric oxide. In the present study, the arginine supplemented group and the coconut protein fed group produced similar effects. These studies clearly demonstrate that coconut protein is able to reduce hyperlipidemia and peroxidative effect induced by high fat cholesterol containing diet and these effects are mainly mediated by the L-arginine present in it.

译文

:研究了高蛋白饮食饮食中椰子蛋白对脂质和脂质过氧化物代谢的影响。另外,将椰子蛋白的作用与饲喂L-精氨酸的大鼠进行了比较。结果表明,喂食椰子蛋白的人和喂食L-精氨酸的人血清中的总胆固醇,LDL VLDL胆固醇,甘油三酸酯和磷脂水平显着降低,而血清HDL胆固醇则升高。这些组中组织中总胆固醇,甘油三酸酯和磷脂的浓度较低。肝胆固醇生成增加,这从标记的乙酸盐掺入游离胆固醇的较高速率中可以明显看出。观察到胆固醇向胆汁酸的转化增加和粪便中胆汁酸的排泄增加。喂养椰子蛋白会导致心脏中丙二醛的水平降低,超氧化物歧化酶和过氧化氢酶的活性增加。补充椰子蛋白会导致尿中硝酸盐的排泄增加,这意味着精氨酸向一氧化氮的转化率更高。在本研究中,精氨酸补充组和椰子蛋白喂养组产生了相似的效果。这些研究清楚地表明,椰子蛋白能够减少高脂胆固醇饮食引起的高脂血症和过氧化作用,这些作用主要是由其中存在的L-精氨酸介导的。

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