The effect of taurine on the serum and liver cholesterol and triglyceride levels was studied in rats fed cholesterol plus cholic acid. Four groups of 4 weeks old rats were fed control diet, hypercholesterolemic diet (HCD), HCD + 1% taurine or HCD + 2% taurine for 8 weeks. Addition of taurine in HCD diet showed a significant reduction not only in serum total cholesterol and triglyceride levels but also in liver total cholesterol, lipid and triglyceride contents compared to the animals fed HCD alone. Histological examination of organs of these animals showed severe fatty vacuolation in livers and signet ring type vacuolation in kidneys of rats fed HCD. Taurine showed ameliorating effect on these abnormalities. The animals fed taurine in HCD also showed increased bile and sterol excretion in faeces compared to rats fed HCD alone. Taurine showed significant hypocholesterolemia in rats probably by enhancing the catabolism of cholesterol and reducing the absorption of dietary cholesterol.

译文

:在饲喂胆固醇加胆酸的大鼠中研究了牛磺酸对血清,肝胆固醇和甘油三酸酯水平的影响。四组4周龄大鼠分别喂食对照饮食,高胆固醇饮食(HCD),1%牛磺酸HCD或2%牛磺酸HCD,持续8周。与单独喂食HCD的动物相比,在HCD饮食中添加牛磺酸不仅显示血清总胆固醇和甘油三酯水平显着降低,而且肝脏总胆固醇,脂质和甘油三酸酯含量显着降低。这些动物器官的组织学检查显示,喂食HCD的大鼠肝脏严重脂肪空泡化,肾上的图章环型空泡化。牛磺酸对这些异常表现出改善作用。与仅喂食HCD的大鼠相比,喂食HCD的牛磺酸的动物粪便中胆汁和固醇的排泄量也增加。牛磺酸可通过增强胆固醇的分解代谢并减少饮食中胆固醇的吸收而显示出明显的低胆固醇血症。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录