OBJECTIVE:To review the presentation of hyperinsulinemic hypoglycemia of the infancy (HHI), its treatment and histology in Brazilian pediatric endocrinology sections. MATERIALS AND METHOD:The protocol analyzed data of birth, laboratory results, treatment, surgery, and pancreas histology. RESULTS:Twenty-five cases of HHI from six centers were analyzed: 15 male, 3/25 born by vaginal delivery. The average age at diagnosis was 10.3 days. Glucose and insulin levels in the critical sample showed an average of 24.7 mg/dL and 26.3 UI/dL. Intravenous infusion of the glucose was greater than 10 mg/kg/min in all cases (M:19,1). Diazoxide was used in 15/25 of the cases, octreotide in 10, glucocorticoid in 8, growth hormone in 3, nifedipine in 2 and glucagon in 1. Ten of the cases underwent pancreatectomy and histology results showed the diffuse form of disease. CONCLUSION:This is the first critic review of a Brazilian sample with congenital HHI.

译文

目的:回顾巴西小儿内分泌科婴儿高胰岛素血症性低血糖症(HHI)的表现,治疗方法和组织学。
材料与方法:该协议分析了出生,实验室结果,治疗,手术和胰腺组织学的数据。
结果:分析了来自六个中心的25例HHI病例:15例男性,3/25通过阴道分娩出生。诊断时的平均年龄为10.3天。关键样品中的葡萄糖和胰岛素水平平均为24.7 mg / dL和26.3 UI / dL。在所有情况下,静脉输注葡萄糖均大于10 mg / kg / min(M:19,1)。乙二氧化物使用15/25,奥曲肽10,糖皮质激素8,生长激素3,硝苯地平2,胰高血糖素1。十例进行了胰腺切除术,组织学结果显示疾病是弥漫性的。
结论:这是对巴西先天性HHI样本的首次评论家评论。

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