BACKGROUND:Endothelial nitric oxide synthase produces nitric oxide which is involved in many physiologic regulatory functions. Variable number of tandem repeats in intron 4 of endothelial nitric oxide synthase gene are reported to be associated with blood pressure regulation. Nitric oxide is involved in regulation of cardiomyocyte genes but it is not known If endothelial nitric oxide synthase 4 gene polymorphisms are related with left ventricular hypertrophy. We studied endothelial nitric oxide synthase 4a/b allele status in hypertensive and normotensive patients and echocardiographic parameters in a subgroup of hypertensive group. METHODS:We performed a case-control study involving 110 Turkish hypertensive patients and 87 controls. All subjects were genotyped for endothelial nitric oxide synthase 4a/b polymorphism. Echocardiographic measurements were obtained in 94 of the hypertensive patients. RESULTS:Endothelial nitric oxide synthase 4a/b genotype frequencies were 6.4%, 23.6%, 70% in hypertensives and 1.1%, 18.4%, 80.5% in controls for a/a, a/b, b/b, respectively. Left ventricular dimensions, mass and diastolic indices were not different across endothelial nitric oxide synthase 4 genotypes. Patients with 4a/a genotype had higher interventricular septal thickness than the other group; 14.83(1.6), 11.91(1.51), 12.21(1.56) for a/a, a/b, b/b, respectively and p = 0.0001. CONCLUSION:Endothelial nitric oxide synthase 4a/b gene polymorphism is not associated with hypertension in Turkish patients. 4a/a genotype was associated with higher interventricular septal thickness in hypertensive patients.

译文

背景:内皮型一氧化氮合酶产生的一氧化氮参与许多生理调节功能。据报道,内皮一氧化氮合酶基因的内含子4中的串联重复数目可变,这与血压调节有关。一氧化氮参与心肌细胞基因的调控,但尚不清楚内皮型一氧化氮合酶4基因多态性是否与左心室肥大有关。我们研究了高血压和血压正常患者的内皮一氧化氮合酶4a / b等位基因状态以及高血压亚组的超声心动图参数。
方法:我们进行了一项病例对照研究,涉及110名土耳其高血压患者和87名对照。对所有受试者的内皮型一氧化氮合酶4a / b多态性进行基因分型。 94名高血压患者获得了超声心动图测量结果。
结果:高血压患者的内皮型一氧化氮合酶4a / b基因型频率分别为6.4%,23.6%,70%和a / a,a / b,b / b对照组的1.1%,18.4%,80.5%。内皮型一氧化氮合酶4基因型的左心室尺寸,质量和舒张指数没有差异。基因型为4a / a的患者的室间隔厚度比另一组高。 a / a,a / b,b / b分别为14.83(1.6),11.91(1.51),12.21(1.56),p = 0.0001。
结论:土耳其人内皮型一氧化氮合酶4a / b基因多态性与高血压无关。基因型4a / a与高血压患者较高的室间隔厚度有关。

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