Plants from Suriname (South-America) and several Annona species, including A. muricata, A. ckerimolia, A. montana and A. glabra were screened for 5-HT(1A) receptor binding activity by ligand-binding-studies (LBS). Crude extracts of all Annona species and from Hibiscus bifurcatus, Irlbarchia purpurascens and Scoparia dulcis showed high activity. The isoquinoline alkaloids asimilobine (1), nornuciferine (2), and annonaine (3) were isolated as the active principles from the fruit of Annona muricata. These results may partially explain the use of Hibiscus bifurcatus and Annona muricata in traditional medicine in Suriname.

译文

通过配体结合研究 (LBS) 筛选了苏里南 (南美) 的植物和几种番荔叶物种,包括A. muricata,A. ckerimolia,A. montana和A. glabra的5-HT(1A) 受体结合活性。所有番荔叶物种的粗提物以及木槿,紫菜和紫菜的粗提物均显示出很高的活性。从番荔叶果实中分离出异喹啉生物碱asimilobine (1),去甲钙碱 (2) 和番荔碱 (3) 作为活性成分。这些结果可能部分解释了苏里南传统医学中芙蓉和番荔叶的使用。

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