We aimed to analyze the potential influence of thyroid autoimmunity on visfatin/NAMPT serum concentration and its leukocyte expression in hyperthyroid patients. This is a single-center, cross-sectional study with consecutive enrollment. All patients with newly diagnosed overt hyperthyroidism in a course of Graves' disease or toxic nodular goiter were included in the study. They underwent physical examination, laboratory investigation, body composition analysis, and thyroid ultrasound. NAMPT mRNA leukocyte expressions were measured using RT-qPCR. Of the 173 patients, 95 were enrolled in further analysis [67 patients with Graves' disease (GD) and 28 with toxic nodular goiter (TNG)]. Control group consisted of 43 healthy volunteers adjusted for age, sex, and BMI. Higher NAMPT/visfatin serum concentration was found in patients with GD comparing with patients with TNG (p=0.03855). We found significant NAMPT leukocyte overexpression in GD patients (n=32) as compared to TNG patients (n=18) and euthyroid controls (n=24) (p=0.005965). Simple linear regression analysis revealed that NAMPT/visfatin serum concentration was significantly associated with NAMPT leukocyte expression, thyroid autoimmunity, age, HOMA-IR, and fat mass percentage (FM%). NAMPT leukocyte expression was related to thyroid autoimmunity, age, and TRAb levels. The stepwise multiple regression analysis revealed FM% and HOMA-IR as independent predictors of visfatin/NAMPT serum levels. In a separate stepwise multiple regression analysis, we confirmed the association between NAMPT leukocyte expression and TRAb levels. We found that fat mass percentage together with HOMA-IR are the most significant predictors of visfatin/NAMPT serum elevation in hyperthyroid patients.

译文

:我们旨在分析甲状腺自身免疫对甲状腺功能亢进患者中的visfatin / NAMPT血清浓度及其白细胞表达的潜在影响。这是一项连续注册的单中心,横断面研究。该研究包括所有新诊断为患有格雷夫斯病或中毒性结节性甲状腺肿的明显甲状腺功能亢进症的患者。他们接受了身体检查,实验室检查,身体成分分析和甲状腺超声检查。使用RT-qPCR测量NAMPT mRNA白细胞表达。在这173例患者中,有95例进行了进一步分析[67例Graves病(GD)和28例中毒性结节性甲状腺肿(TNG)]。对照组由43位经过年龄,性别和BMI调整的健康志愿者组成。与TNG患者相比,GD患者的NAMPT / visfatin血清浓度更高(p = 0.03855)。我们发现,与TNG患者(n = 18)和甲状腺正常对照(n = 24)相比,GD患者(n = 32)有明显的NAMPT白细胞过表达(p = 0.005965)。简单的线性回归分析显示,NAMPT / visfatin血清浓度与NAMPT白细胞表达,甲状腺自身免疫性,年龄,HOMA-IR和脂肪质量百分比(FM%)显着相关。 NAMPT白细胞表达与甲状腺自身免疫性,年龄和TRAb水平相关。逐步多元回归分析显示FM%和HOMA-IR是visfatin / NAMPT血清水平的独立预测因子。在单独的逐步多元回归分析中,我们确认了NAMPT白细胞表达与TRAb水平之间的关联。我们发现,脂肪质量百分比与HOMA-IR一起是甲状腺功能亢进患者中visfatin / NAMPT血清升高的最重要预测因子。

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