Antenatal and postnatal environments are hypothesised to influence the development of hypertension. This study investigates the synergistic effect of cross-fostering and melatonin supplementation on the development of hypertension and renal glutathione system in spontaneously hypertensive rats (SHR). In one experiment, 1-day-old male SHR pups were fostered to either SHR (shr-SHR) or Wistar-Kyoto rats, (shr-WKY). In a concurrent experiment, SHR dams were given melatonin in drinking water (10 mg/kg body weight) from day 1 of pregnancy. Immediately following delivery, 1-day-old male pups were fostered either to SHR (Mel-shr-SHR) or WKY (Mel-shr-WKY) dams receiving melatonin supplementation until weaning on day 21. Upon weaning, melatonin supplementation was continued to these pups until the age of 16 weeks. Systolic blood pressures (SBP) were recorded at the age of 4, 6, 8, 12 and 16 weeks. Renal antioxidant activities were measured. Mean SBP of shr-WKY, Mel-shr-SHR and Mel-shr-WKY was significantly lower than that in shr-SHR until the age of 8 weeks. At 12 and 16 weeks of age, mean SBP of Mel-shr-WKY was lower than those in non-treated shr-SHR and shr-WKY pups but was not significantly different from that in Mel-shr-SHR. Renal glutathione peroxidase (GPx) and glutathione S-transferase (GST) activities were significantly higher in Mel-shr-SHR and Mel-shr-WKY at 16 weeks of age. It appears that combination of cross-fostering and melatonin supplementation exerts no synergistic effect on delaying the rise in blood pressure in SHR. The elevated GPx and GST activities are likely to be due to the effect of melatonin supplementation.

译文

:假设产前和产后环境会影响高血压的发展。这项研究调查了交叉养育和褪黑素补充对自发性高血压大鼠(SHR)高血压和肾脏谷胱甘肽系统发育的协同作用。在一项实验中,将1日龄的雄性SHR幼犬饲养到SHR(shr-SHR)或Wistar-Kyoto大鼠(shr-WKY)中。在一项并行实验中,从怀孕的第一天开始,在SHR大坝中的饮用水中(以体重10 mg / kg体重)给予褪黑激素。分娩后立即将1日龄的雄性幼犬饲养到接受褪黑激素补充的SHR(Mel-shr-SHR)或WKY(Mel-shr-WKY)水坝,直到第21天断奶。断奶后,继续补充褪黑素至这些幼犬直到16周龄。在4、6、8、12和16周龄时记录收缩压(SBP)。测量了肾脏的抗氧化活性。直到8周龄,shr-WKY,Mel-shr-SHR和Mel-shr-WKY的平均SBP均显着低于shr-SHR。在12周和16周龄时,Mel-shr-WKY的平均SBP低于未处理的shr-SHR和shr-WKY幼犬的SBP,但与Mel-shr-SHR的SBP并无显着差异。在16周龄时,Mel-shr-SHR和Mel-shr-WKY的肾脏谷胱甘肽过氧化物酶(GPx)和谷胱甘肽S-转移酶(GST)活性显着更高。似乎交叉培育和褪黑激素补充对延迟SHR血压升高没有协同作用。 GPx和GST活性升高可能是由于补充褪黑激素的影响。

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