The embryotoxicity/teratogenicity of the sugar replacer isomalt was studied in Wistar rats and New Zealand White rabbits. Groups of 22-23 female rats were given diets containing isomalt at concentrations of 2.5, 5 or 10%, from day 0 to day 21 of pregnancy. The possible adverse effects of restricted feeding were studied in an additional group (food intake less than 80% of the control values). Groups of 36-37 female rabbits were given diets containing isomalt at concentrations of 2.5, 5 or 10%, from day 0 to day 29 of pregnancy. The female rats and rabbits were killed on days 21 and 29 of pregnancy, respectively. In both species no maternal toxicity occurred and no effects on reproductive performance nor on embryonic or foetal development were seen in any of the groups fed isomalt. The feeding of restricted amounts of stock diet to pregnant rats resulted in decreased maternal weight gain and lower uterus weights. Furthermore, this group had an increased number of resorptions and small foetuses, decreased foetus and placental weights and retarded bone development.

译文

:在Wistar大鼠和新西兰白兔中研究了糖替代品异麦芽酮糖的胚胎毒性/致畸性。从怀孕的第0天到第21天,对22-23只雌性大鼠组给予含异麦芽酮糖的饮食,其浓度为2.5%,5%或10%。在另一组中研究了限制进食的可能的不良影响(食物摄入量少于对照值的80%)。从怀孕的第0天到第29天,给每组36-37只雌性兔子饲喂含有2.5、5%或10%异麦芽酮糖的饮食。雌性大鼠和兔子分别在怀孕的第21天和第29天被杀死。在这两个物种中,没有任何母体毒性发生,并且在饲喂异麦芽酮糖的任何组中均未见对生殖性能,胚胎或胎儿发育有影响。向怀孕的大鼠喂食有限量的基础饮食会导致孕产妇体重增加减少和子宫重量降低。此外,该组的吸收增加,胎儿少,胎儿和胎盘重量减少,骨骼发育受阻。

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