Hypercalcemia in accelerated phase of chronic myelogenous leukemia (CML) is very rare. Its pathogenesis is considered humoral hypercalcemia of malignancies mediated by parathyroid hormone-related protein (PTHrP). In severe hypercalcemia, calcifications in kidneys, skin, vessels, heart, and stomach may occur. Our two cases were admitted because of severe hypercalcemia in accelerated phase of CML. On Tc-99m methylene diphosphonate (MDP) bone scintigraphies, a marked tracer accumulation was seen in the lung, heart, stomach and kidney. We report increased tracer accumulation of multiple organs on Tc-99m MDP bone scintigraphy in two rare hypercalcemic patients with CML.

译文

:慢性粒细胞性白血病(CML)加速期的高钙血症非常罕见。其发病机理被认为是由甲状旁腺激素相关蛋白(PTHrP)介导的恶性体液性高钙血症。在严重的高钙血症中,可能会在肾脏,皮肤,血管,心脏和胃中发生钙化。我们的两个病例是由于CML加速期严重的高钙血症而入院的。在Tc-99m二磷酸二甲酯(MDP)骨显像仪上,在肺,心脏,胃和肾脏中发现了明显的示踪剂蓄积。我们报告了两名罕见的高钙血症伴CML患者在Tc-99m MDP骨闪烁显像仪上多个器官的示踪剂积累增加。

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