The immune cell products interleukins 1 alpha and -beta, which stimulate osteoclast activity in vitro, are among the most potent bone resorbing factors so far described. Although it appears likely that these cytokines are involved in regulation of trabecular bone turnover, nothing is known of their effects on extracellular fluid calcium concentration. In this report, we show the effects of 72-hr subcutaneous infusions of interleukins 1 alpha and -beta on plasma calcium and bone morphology in mice. Both interleukins 1 caused a marked dose-dependent increase in the plasma calcium. In higher doses, which cause the animals to die, the plasma calcium fell preterminally. Quantitative histomorphometry of bone sections showed evidence of increased numbers of osteoclasts and bone resorption surfaces. The effects were similar to those obtained with infusions of parathyroid hormone. These data suggest that in addition to its potential influence on trabecular bone volume, interleukin 1 may also modulate extracellular fluid calcium homeostasis under conditions in which it is produced excessively.

译文

免疫细胞产物白细胞介素1α和-β在体外刺激破骨细胞活性,是迄今为止描述的最有效的骨吸收因子之一。尽管这些细胞因子似乎参与了小梁骨周转的调节,但尚不清楚它们对细胞外液钙浓度的影响。在此报告中,我们显示了白细胞介素1α和-β皮下输注72小时对小鼠血浆钙和骨形态的影响。两种白介素1均引起血浆钙的显着剂量依赖性增加。高剂量会导致动物死亡,血浆钙会先期下降。骨切片的定量组织形态计量学显示出破骨细胞和骨吸收表面数量增加的证据。效果类似于输注甲状旁腺激素所获得的效果。这些数据表明,白细胞介素1除了对小梁骨体积的潜在影响外,在其产生过多的条件下,白细胞介素1还可能调节细胞外液钙稳态。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录