Changes in the serum levels of gonadotrophins and steroid hormones with increasing age were studied in 449 women aged 40 and over to investigate the relationships between these hormones even very late in life. The levels of oestradiol (E2) and dehydroepiandrosterone sulphate (DHEA-S) fell after age 50 and remained low thereafter. However, while serum oestrone (E1), testosterone (T), delta-4-androstenedione (A) and prolactin (PRL) concentrations also decreased initially after age 50 they subsequently rose again progressively and this increase was in fact significant in the case of E1. Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) rose after age 50, but whereas FSH remained elevated, LH decreased late in life. Cortisol (F) increased significantly after age 70. There was a significant correlation between androgens and E1 as well as between E2 and LH, even after age 60. Owing to the great heterogeneity of the population studied, it is not yet possible to speculate as to the physiopathological significance of these observations. It would seem, however, that the negative feedback effect of oestrogens on LH secretion remains operational very late in life.

译文

:研究了449名40岁及以上的女性随年龄增长而引起的血清促性腺激素和类固醇激素水平的变化,以调查这些激素之间的关系,甚至在生命的最晚时期也是如此。雌二醇(E2)和脱氢表雄酮硫酸盐(DHEA-S)的水平在50岁以后下降,此后保持较低水平。然而,尽管血清雌酮(E1),睾丸激素(T),δ4-雄烯二酮(A)和催乳激素(PRL)的浓度在50岁以后也开始下降,但随后又逐渐上升,实际上,对于E1。黄体生成素(LH)和促卵泡激素(FSH)在50岁以后上升,但是FSH保持升高,而LH在生命后期下降。皮质醇(F)在70岁以后显着增加。即使在60岁以后,雄激素和E1之间以及E2和LH之间也存在显着相关性。由于所研究人群的巨大异质性,尚无法推测这些观察的生理病理意义。但是,似乎雌激素对LH分泌的负反馈作用在生命的最后阶段仍然有效。

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