Wound dressings are the primary barrier between the wound surface and the outer environment. Here we report the fabrication of cellulose acetate (CA)-Manuka honey (MH) composite nanofibrous mats as a biocompatible and antimicrobial wound dressing. CA mats with different quantities of MH were developed by electrospinning. The ATR-FTIR spectra confirm the inclusion of MH in the composite CA-MH nanofibrous mats. The fibers were continuous and bead-free with acceptable mechanical properties. The fiber diameter increased with an increase in MH content. Inclusion of MH in the electrospun composite CA-MH nanofibrous mats shows high efficacy to prevent bacterial growth on the wound surface. The MH loaded CA nanofiber mats showed good antioxidant abilities, while the ability to free radicalize the DPPH was dependent upon the factors of MH content in the fiber and the time of immersion in the DPPH solution. Besides, the nanofibrous mat's high porosity (85-90%) and WVTR values of 2600 to 1950 g/m2/day, suitable for wound breathability and the mats show high cytocompatibility to NIH 3T3 cell line in in vitro testing, proving to be effective for promoting wound healing.

译文

:伤口敷料是伤口表面与外部环境之间的主要屏障。在这里,我们报告制造醋酸纤维素(CA)-Manuka蜂蜜(MH)复合纳米纤维垫作为生物相容性和抗菌伤口敷料。通过静电纺丝开发了具有不同MH量的CA毡。 ATR-FTIR光谱确认了复合CA-MH纳米纤维毡中包含MH。纤维是连续的且无珠子,具有可接受的机械性能。纤维直径随着MH含量的增加而增加。在电纺复合CA-MH纳米纤维垫中包含MH可以有效防止伤口表面细菌生长。 MH负载的CA纳米纤维垫具有良好的抗氧化能力,而使DPPH自由基化的能力取决于纤维中MH含量的因素以及在DPPH溶液中浸泡的时间。此外,该纳米纤维垫的高孔隙率(85-90%)和WVTR值为2600至1950 g / m2 /天,适合伤口透气性,并且在体外测试中该垫对NIH 3T3细胞系显示出高度的细胞相容性,证明是有效的促进伤口愈合。

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