BACKGROUND:Monitoring infectivity markers in multi-transfused patients is an important indicator of the efficiency and quality of testing in blood centers. This study is part of a regional initiative to bring both national and regional attention to the problem of hepatitis C, compare the threat of HCV to that of HBV and HIV; assess the risks for viral infection of using different blood products and implementing different transfusion practices, and contribute to a better understanding of the state of blood safety in the region. STUDY DESIGN AND METHODS:A cross sectional study was conducted from September 2002 to August 2003 and included multi-transfused patients from eight private, public and Social Security hospitals from Tegucigalpa and San Pedro Sula, Honduras. A survey was completed for each patient which included demographic and clinical data. Patients were tested for HBsAg, anti-HBc, anti-HIV and anti-HCV Effects of the exposure to blood products, to whole blood; to lyophilized factor VIII in patients living with hemophilia on the prevalence of HBV, HCV and HIV infection were evaluated. RESULTS:Five hundred and two patients were enrolled in the study; 11% were positive for HBsAg; 27% for anti-HBc; 7% for HCV and 1% for HIV One point six percent of hemophilia patients were positive for HBsAg; 38% were positive for anti-HBc and 26.9% for HCV A dose effect between the exposure to blood products and prevalence of HCV was found (p < 0.05). It was not possible to show a dose effect between the exposure to blood products and prevalence of either HBV or HIV in any of the subpopulations studied. CONCLUSIONS:The transfusion of blood products seems to be the main factor for HCV seropositivity in the subpopulation of patients studied. Additional work is needed to elucidate the risk factors associated with HBV infection in Honduras.

译文

背景:监测多次输血患者的感染性标志物是血液中心检测效率和质量的重要指标。这项研究是一项地区计划的一部分,旨在使国家和地区都关注丙型肝炎问题,将HCV的威胁与HBV和HIV的威胁进行比较;评估使用不同血液制品和实施不同输血方法引起的病毒感染风险,并有助于更好地了解该地区的血液安全状况。
研究设计和方法:2002年9月至2003年8月进行了一项横断面研究,纳入了来自洪都拉斯特古西加尔巴和圣佩德罗苏拉的八家私立,公立和社会保障医院的多次输血患者。已完成对每位患者的调查,其中包括人口统计学和临床​​数据。对患者进行了HBsAg,抗HBc,抗HIV和抗HCV检测。评估血友病患者冻干因子VIII对HBV,HCV和HIV感染的患病率。
结果:本研究共纳入502例患者。 HBsAg阳性的占11%;抗HBc的27%; HCV为7%,HIV为1%。6%的血友病患者HBsAg阳性。抗HBc阳性38%,HCV阳性26.9%。发现从血液制品接触到HCV流行之间存在剂量效应(p <0.05)。在所研究的任何亚人群中,都不可能显示出暴露于血液制品与HBV或HIV患病率之间的剂量效应。
结论:输血似乎是所研究患者亚群中HCV血清阳性的主要因素。需要进一步的工作来阐明洪都拉斯与HBV感染相关的危险因素。

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