Previous research showed that ferrets of both sexes rely on the perception of conspecifics' body odors to identify and motivate approach towards opposite-sex mating partners, and exposure to male body odors stimulated Fos expression in an olfactory projection circuit of female, but not male, ferrets that terminates in the ventromedial hypothalamic nucleus (VMH). We asked whether the female-typical preference of ferrets to approach male as opposed to female body odors in Y-maze tests would be disrupted by VMH lesions. Sexually experienced female ferrets were ovo-hysterectomized prior to receiving bilateral electrolytic lesions of the VMH, the preoptic area/anterior hypothalamus (POA/AH) or a sham operation. Subsequently, while receiving estradiol benzoate, females that received either complete or partial bilateral lesions of the VMH approached volatile odors from an anesthetized male on significantly fewer trials than females given POA/AH lesions or a sham operation. Both groups of ferrets with VMH lesion damage reliably discriminated between volatile anal scents as well as urinary odors from the 2 sexes in home cage habituation/dishabituation tests, suggesting that their odor-based sex discrimination remained intact. Females with complete bilateral VMH lesions showed significantly lower acceptance of neck gripping from a stimulus male (receptivity) and more aggression towards the male than all other groups of female subjects. Estrogen-sensitive neurons in the VMH appear to play a central role in female-typical neural processing of odor inputs leading to a preference to seek out a male sex partner, in addition to facilitating females' sexual receptivity.

译文

:先前的研究表明,两性雪貂都依靠对同种物种的体味的感知来识别和激发异性交配伴侣的方式,而暴露于男性的体味会刺激雌性而不是雄性的嗅觉投射回路中的Fos表达,终止于腹膜下丘脑核(VMH)的雪貂。我们询问在VMH病变中,雪貂在Y型迷宫测试中对女性趋向于男性而不是女性具有典型的雌性偏爱。有性经历的雌性雪貂在接受VMH的双侧电解损伤,视前区/下丘脑前部(POA / AH)或假手术前进行了子宫切除术。随后,在接受雌二醇苯甲酸酯治疗的同时,接受了VMH完全或部分双侧病变的雌性从麻醉的男性接近挥发性气味,在试验中,接受POA / AH病变或假手术的女性明显少于女性。在笼养习性/适应性测试中,两组VMH损伤的雪貂都能可靠地区分挥发性的肛门气味和两种性别的尿臭味,这表明他们基于气味的性别歧视仍然完好无损。与所有其他女性受试者相比,具有完全双侧VMH病变的女性表现出的刺激男性对颈部抓握的接受度(接受度)显着降低,并且对男性的攻击性更高。 VMH中对雌激素敏感的神经元似乎在女性典型的气味输入神经处理中起着核心作用,除了促进女性的性接受能力外,导致倾向于寻找男性伴侣。

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