New developments in stent technology led to the first biodegradable magnesium stents. To overcome the fundamental restrictions of conventional stent implantation, these new stents may improve interventional therapy, also in small children. What remains after complete degradation of a magnesium stent is of particular interest and concern. At the autopsy, 2 months after the projected complete degradation time of the 3.0 x 10 mm(2) stent, no solid compounds were detected, and the vessel diameter had increased slightly to 3.7 mm. Histological preparation revealed an amorphous to jelly-like substitute of the magnesium struts mainly consisting of calcium phosphate covered by fibrotic tissue. Immunological staining revealed no relevant inflammatory reaction to the stent material. Neointima proliferation was detected around the struts with some cellular infiltration of the calcium-phosphate material. These pathological and histological findings show minimal alteration of the vessel wall and an increase of the arterial diameter after stent degradation. This is an important precondition for further use of biodegradable stents in small infants. Further observations have to prove whether these findings do reproduce in other settings also.

译文

:支架技术的新发展导致了首个可生物降解的镁支架。为了克服常规支架植入的基本限制,这些新的支架可能会改善介入治疗,甚至在儿童中也是如此。镁支架完全降解后剩下的东西是特别令人关注和关注的。在尸体解剖中,在预计的3.0 x 10 mm(2)支架完全降解时间之后2个月,没有检测到固体化合物,并且血管直径略微增加到3.7 mm。组织学制备显示镁柱的无定形至果冻状替代物,其主要由被纤维化组织覆盖的磷酸钙组成。免疫染色显示与支架材料无相关的炎症反应。在细胞周围渗透了磷酸钙物质后,在支杆周围检测到了新内膜增生。这些病理学和组织学结果显示,支架降解后,血管壁的改变最小,动脉直径增加。这是在婴儿中进一步使用可生物降解支架的重要前提。进一步的观察必须证明这些发现是否也能在其他环境中重现。

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