We studied the influence of aprotinin and soya bean trypsin inhibitor (SBTI) on the inflammatory reaction induced by the implantation of dry sponges in normal Wistar rats and in kininogen-deficient Brown Norway rats, during the first day after the implantation. In normal rats, aprotinin reduced the volume and total protein content of the exudates at 3 h but not thereafter. Aprotinin also markedly reduced the immunoreactive kinins and kallikrein in the exudates. Aprotinin did not modify the volume of the exudates of the Brown Norway rats. SBTI reduced the inflammatory reaction in both rat strains but did not significantly modify the formation of immunoreactive kinins. The inflammatory reaction developed more slowly in Brown Norway rats. The kinin system is thus involved during the first hours of the development of this acute inflammatory reaction. The anti-inflammatory effect of SBTI does not depend on the inhibition of kinin formation.

译文

:我们研究了抑肽酶和大豆胰蛋白酶抑制剂(SBTI)在植入后第一天对正常Wistar大鼠和缺乏激肽原的褐挪威大鼠中植入干海绵诱导的炎症反应的影响。在正常大鼠中,抑肽酶在3小时后降低了分泌液的体积和总蛋白含量,但此后没有降低。抑肽酶还显着降低渗出液中的免疫反应激肽和激肽释放酶。抑肽酶未改变棕色挪威大鼠渗出液的体积。 SBTI减少了两种大鼠品系中的炎症反应,但并未显着改变免疫反应激肽的形成。在布朗挪威大鼠中,炎症反应发展得较慢。因此,激肽系统参与了这种急性炎症反应发展的最初几个小时。 SBTI的抗炎作用不取决于对激肽形成的抑制作用。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录