Histone methylation has important roles in regulating gene expression and forms part of the epigenetic memory system that regulates cell fate and identity. Enzymes that directly remove methyl marks from histones have recently been identified, revealing a new level of plasticity within this epigenetic modification system. Here we analyse the evolutionary relationship between Jumonji C (JmjC)-domain-containing proteins and discuss their cellular functions in relation to their potential enzymatic activities.

译文

:组蛋白甲基化在调节基因表达中起重要作用,并形成表观遗传记忆系统的一部分,该系统调节细胞命运和特性。最近已鉴定出可直接从组蛋白中去除甲基标记的酶,从而揭示了该表观遗传修饰系统中可塑性的新水平。在这里,我们分析Jumonji C(JmjC)域包含蛋白质之间的进化关系,并讨论其潜在的酶活性与其细胞功能。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录