The aim of this study was to assess the relationships among the detection of p24 antigen, human immunodeficiency virus (HIV) RNA level, CD4 cell count, and disease progression in 111 males with hemophilia who were infected with HIV for < or =20 years. Sixty-four individuals (58%) developed p24 antigenemia a median of 11.6 years after seroconversion. The time to first detection of p24 antigen was shorter among those who were older (P=.04) and those with a high initial HIV RNA level (P=.006). The median HIV RNA level and CD4 cell count at the time of the detection of p24 antigen were 4.95 log(10) copies/mL and 100 cells/mm(3), respectively. In univariate analyses, p24 antigenemia was associated with more-rapid progression to AIDS (relative hazard [RH], 5.50; P=.0001). The effect was reduced (RH, 1.85; P=.06) after adjusting for CD4 cell counts and HIV RNA levels during follow-up, age, and calendar year. A significant relationship between p24 antigenemia and death was nonsignificant after adjusting for CD4 cell count.
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【Relationships among the detection of p24 antigen, human immunodeficiency virus (HIV) RNA level, CD4 cell count, and disease progression in HIV-infected individuals with hemophilia.].
【在感染了血友病的HIV感染者中，p24抗原的检测，人类免疫缺陷病毒（HIV）RNA水平，CD4细胞计数和疾病进展之间的关系。】
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DOI：10.1086/322045文章类型：杂志文章
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：这项研究的目的是评估111岁以下感染HIV或≤20年的血友病男性的p24抗原检测，人类免疫缺陷病毒（HIV）RNA水平，CD4细胞计数和疾病进展之间的关系。 。血清转化后的中位值是11.6年，其中有64个人（58％）患了p24抗原血症。在年龄较大的患者（P = .04）和初始HIV RNA水平高的患者（P = .006）中，首次检测p24抗原的时间较短。检测p24抗原时的HIV RNA中位数和CD4细胞计数中位数分别为4.95 log（10）个拷贝/ mL和100个细胞/ mm（3）。在单因素分析中，p24抗原血症与更快速地发展为AIDS有关（相对危险度[RH]，5.50； P = .0001）。在随访，年龄和日历年中调整CD4细胞计数和HIV RNA水平后，效果降低（RH，1.85； P = .06）。调整CD4细胞计数后，p24抗原血症与死亡之间的显着关系不显着。
