Signalling through the ERBB/HER receptors is intricately involved in human cancer and already serves as a target for several cancer drugs. Because of its inherent complexity, it is useful to envision ERBB signalling as a bow-tie-configured, evolvable network, which shares modularity, redundancy and control circuits with robust biological and engineered systems. Because network fragility is an inevitable trade-off of robustness, systems-level understanding is expected to generate therapeutic opportunities to intercept aberrant network activation.

译文

:通过ERBB / HER受体进行信号传递与人类癌症错综复杂,并且已经成为多种抗癌药物的靶标。由于其固有的复杂性,将ERBB信令设想为领结式配置,可演进的网络非常有用,该网络与健壮的生物和工程系统共享模块化,冗余性和控制电路。由于网络脆弱性是鲁棒性的必然折衷,因此系统级的理解有望产生治疗机会,以拦截异常的网络激活。

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