INTRODUCTION:Suicide is known as a major health concern worldwide. There is evidence for the role of brain-derived neurotrophic factor (BDNF) in suicide behavior. Therefore, this factor has been proposed as a biomarker for suicide behavior. Clinical studies have measured BDNF concentrations at central and peripheral levels. As a consequence, the aim of this study was to assess BDNF levels in blood plasma and serum to see whether there is a difference in concentrations in patients with suicide behavior when compared to those in controls, using a meta-analysis approach. METHODS:We conducted a systematic review and meta-analysis. The search strategy was performed using three databases: PubMed, EBSCO and ScienceDirect. The meta-analysis included a total of nine case-control studies, six measured the BDNF level in serum and three in plasma in suicide behavior. RESULTS:A decrease in BDNF levels in plasma was observed (d = -0.73, 95% CI -1.42 to -0.03 pg/ml). In the case of serum concentrations, no BDNF differences were encountered between cases and controls (d = 0.09, 95% CI -0.31 to 0.13 ng/ml, p(Q) = .92). CONCLUSIONS:According to the results found in the present meta-analysis, the plasma BDNF level could be suggest as a potential biomarker in suicide behavior. However, since the number of studies included in the analysis is limited, a larger number is necessary to determine conclusively the role of BDNF as a biomarker in suicide behavior.

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简介:自杀是全球公认的主要健康问题。有证据表明脑源性神经营养因子(BDNF)在自杀行为中的作用。因此,已经提出该因素作为自杀行为的生物标记。临床研究已经测量了中枢和外周水平的BDNF浓度。因此,这项研究的目的是使用荟萃分析方法评估血浆和血清中BDNF的水平,以查看自杀行为患者与对照组相比是否存在浓度差异。
方法:我们进行了系统的回顾和荟萃分析。搜索策略是使用三个数据库执行的:PubMed,EBSCO和ScienceDirect。荟萃分析包括九项病例对照研究,六项测量血清BDNF水平,三项血浆自杀行为。
结果:血浆中BDNF水平下降(d = -0.73,95%CI -1.42至-0.03 pg / ml)。就血清浓度而言,病例与对照之间未见BDNF差异(d = 0.09,95%CI -0.31至0.13ng / ml,p(Q)= 0.92)。
结论:根据目前的荟萃分析结果,血浆BDNF水平可能被认为是自杀行为的潜在生物标志物。但是,由于分析中包含的研究数量有限,因此有必要大量研究来确定BDNF作为自杀行为中生物标志物的作用。

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