Previous human imaging studies have revealed a network of brain regions involved in the processing of allodynic pain; this includes prefrontal areas, insula, cingulate cortex, primary and secondary somatosensory cortices and parietal association areas. In this study, the neural correlates of the perceived intensity of allodynic pain in neuropathic pain patients were investigated. In eight patients, dynamic mechanical allodynia was provoked and brain responses recorded using functional magnetic resonance imaging (fMRI). Voxels in which the magnitude of fMRI signal correlated linearly with the ratings of allodynic pain across the group were determined in a whole brain analysis using a general linear model. To ensure that activation reflected only allodynic pain ratings, a nuisance variable containing ratings of ongoing pain was included in the analysis. We found that the magnitude of activation in the caudal anterior insula (cAI) correlates with the perceived intensity of allodynic pain across subjects, independent of the level of ongoing pain. However, the peak of activation in the allodynic condition was located in the rostral portion (rAI). This matches the representation of other clinical pain syndromes, confirmed by a literature review. In contrast, experimental pain in healthy volunteers resides predominantly in the cAI, as shown by the same literature review. Taken together, our data and the literature review suggest a functional segregation of anterior insular cortex.

译文

先前的人类影像学研究揭示了参与异型疼痛处理的大脑区域网络; 这包括前额叶区域,岛叶,扣带回皮层,初级和次级体感皮层以及顶叶关联区域。在这项研究中,研究了神经性疼痛患者的异常性疼痛感知强度的神经相关性。在八名患者中,使用功能磁共振成像 (fMRI) 引起了动态机械性异常性疼痛,并记录了大脑反应。在使用一般线性模型的全脑分析中,确定了fMRI信号的大小与全组异常性疼痛的等级线性相关的体素。为了确保激活仅反映异常性疼痛等级,分析中包括了包含持续疼痛等级的滋扰变量。我们发现,尾部前岛岛 (cAI) 的激活程度与整个受试者的异常性疼痛的感知强度相关,而与持续疼痛的水平无关。然而,异常性状态下的激活峰值位于鼻尖部分 (rAI)。这与文献综述证实的其他临床疼痛综合征的表现相匹配。相反,如同一文献综述所示,健康志愿者的实验性疼痛主要发生在cAI中。综上所述,我们的数据和文献综述表明,前岛叶皮层具有功能性分离。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录