OBJECTIVE:The 24-hour creatinine clearance is the standard clinical technique for measuring kidney function; however, this measurement is cumbersome and inconvenient for patients. We hypothesized that a camera-based technetium-99m mercaptoacetyltriglycine (MAG3) clearance obtained simultaneously with a standard MAG3 scan would correlate well with the 24-hour creatinine clearance and could serve as a simple marker of kidney function. MATERIALS AND METHODS:Data were obtained from a retrospective analysis of 28 patients with varying degrees of kidney dysfunction and 85 subjects evaluated for kidney donation. The MAG3 clearance was calculated using a camera-based technique without blood or urine sampling. The creatinine clearance was measured using the plasma creatinine and a 24-hour urine collection. The MAG3 and creatinine clearances were corrected for body surface area, and clearance values in healthy subjects and patients were compared using the paired Student's t test. The linear association between the MAG3 and creatinine clearances was expressed by Pearson's correlation coefficient. RESULTS:The mean MAG3 clearance in the potential kidney donors was 321 +/- 95 mL/min/1.73 m2 (95% CI, 171-546 mL/min/1.73 m2), significantly higher than the mean creatinine clearance of 152 +/- 51 mL/min/1.73 m2 (79-278 mL/min/1.73 m2, p < 0.001). The mean MAG3 clearance in patients was 153 +/- 70 mL/min/1.73 m2 (32-316 mL/min/1.73 m2) and was also significantly higher than the mean creatinine clearance of 74 +/- 36 mL/min/1.73 m2 (21-138 mL/min/1.73 m2, p < 0.001). The ratio of the mean creatinine clearance to the mean MAG3 clearance was essentially the same for volunteers and patients, 0.47 and 0.48, respectively. The Pearson's correlation between the MAG3 and creatinine clearances was 0.80 (0.72-0.86). CONCLUSION:The camera-based 99mTc-MAG3 clearance correlates well with the 24-hour creatinine clearance and can provide a simple and convenient index of kidney function.

译文

目的:24小时肌酐清除率是衡量肾脏功能的标准临床技术。然而,这种测量对于患者而言是麻烦且不便的。我们假设与标准MAG3扫描同时获得的基于相机的tech 99m巯基乙酰基三甘氨酸(MAG3)清除率与24小时肌酐清除率相关性很好,并且可以用作肾脏功能的简单标记。
材料与方法:数据来自对28位不同程度的肾功能不全患者的回顾性分析,并对85位受试者的肾脏捐赠进行了评估。 MAG3清除率是使用基于相机的技术计算的,无需进行血液或尿液采样。使用血浆肌酐和24小时尿液收集来测量肌酐清除率。校正了MAG3和肌酐的清除率以进行表面积测定,并使用配对的Student's t检验比较了健康受试者和患者的清除率值。 MAG3和肌酐清除率之间的线性关联由皮尔逊相关系数表示。
结果:潜在肾脏供体的平均MAG3清除率为321 /-95 mL / min / 1.73 m2(95%CI,171-546 mL / min / 1.73 m2),显着高于平均肌酐清除率152 /-51 mL / min / 1.73平方米(79-278 mL / min / 1.73平方米,p <0.001)。患者的平均MAG3清除率为153 /-70 mL / min / 1.73 m2(32-316 mL / min / 1.73 m2),也显着高于平均肌酐清除率74 /-36 mL / min / 1.73 m2( 21-138 mL / min / 1.73 m2,p <0.001)。志愿者和患者的平均肌酐清除率与平均MAG3清除率之比基本相同,分别为0.47和0.48。 MAG3和肌酐清除率之间的Pearson相关性为0.80(0.72-0.86)。
结论:基于相机的99mTc-MAG3清除率与24小时肌酐清除率相关性良好,可以提供简单便捷的肾脏功能指标。

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