The effect of epinephrine on leucine and phenylalanine kinetics was measured by using the stable isotope amino acid tracers L-[1-(13)C]leucine and L-[phenyl-2H5]-phenylalanine in the postabsorptive state and during the intravenous administration of a standard amino acid solution with respect to the amino acid load. Infusion of epinephrine (plasma concentrationapproximately 3600 pmol/L) decreased leucine and phenylalanine and increased ketoisocaproate plasma concentrations and increased the metabolic clearance rate of leucine and phenylalanine. Epinephrine neither influenced leucine or phenylalanine flux nor leucine oxidation or leucine net balance. Hyperaminoacidemia from amino acid infusion reduced endogenous leucine release and stimulated leucine oxidation and nonoxidative disposal of leucine, resulting in a dose-dependent increase in leucine net balance. Epinephrine did not influence any changes in amino acid kinetics during parenteral amino acid administration. Therefore, we conclude that epinephrine had no catabolic effects on amino acid metabolism and no negative effect on the utilization of a parenterally offered amino acid solution in healthy humans.

译文

肾上腺素对亮氨酸和苯丙氨酸动力学的影响通过使用稳定的同位素氨基酸示踪剂L- [1-(13)C]亮氨酸和L- [苯基-2H5]-苯丙氨酸在吸收后的状态下和静脉内给予相对于氨基酸负载的标准氨基酸溶液。输注肾上腺素(血浆浓度约为3600 pmol / L)会降低亮氨酸和苯丙氨酸,增加酮异己酸血浆浓度,并增加亮氨酸和苯丙氨酸的代谢清除率。肾上腺素既不影响亮氨酸或苯丙氨酸通量,也不影响亮氨酸氧化或亮氨酸净平衡。来自氨基酸输注的高氨基酸血症减少了内源性亮氨酸的释放,并刺激了亮氨酸的氧化和亮氨酸的非氧化处置,从而导致了亮氨酸净平衡的剂量依赖性增加。肾上腺素不影响肠胃外氨基酸给药过程中氨基酸动力学的任何变化。因此,我们得出结论,肾上腺素对氨基酸的代谢没有分解代谢作用,对健康人肠胃外提供的氨基酸溶液的利用也没有负面影响。

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