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Genetic studies have recently revealed a role for transforming growth factor-beta-1 (TGF-beta 1) and its receptors (TGF-beta Rs I and II as well as endoglin) in embryonic vascular assembly and in the establishment and maintenance of vessel wall integrity. The purpose of this review is threefoldfirst, to reassess previous studies on TGF-beta and endothelium in the light of these recent findings; second, to describe some of the well-established as well as controversial issues concerning TGF-beta and its regulatory role in angiogenesis; and third, to explore the notion of "context' with respect to TGF-beta and endothelial cell function. Although the focus of this review will be on the endothelium, other vascular wall cells are also likely to be important in the pathogenesis of the vascular lesions revealed by genetic studies.

译文

遗传研究最近揭示了在胚胎血管组装以及血管壁的建立和维持中转化生长因子-β-1(TGF-β1)及其受体(TGF-βRs I和II以及内皮糖蛋白)的作用。正直。这篇综述的目的是三重的,以根据这些最新发现重新评估先前对TGF-β和内皮的研究。其次,描述有关TGF-beta及其在血管生成中的调控作用的一些公认的和有争议的问题;第三,探讨有关TGF-β和内皮细胞功能的“背景”概念,尽管本综述的重点是内皮,但其他血管壁细胞也可能在血管的发病机理中起重要作用。通过遗传学研究发现病变。

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