OBJECTIVE:To study the effects of green tea extract administration on age-related cognition in young and old male Wistar rats.
METHODS:Young and old rats were orally administered 0.5% green tea extract for a period of eight weeks and were evaluated by passive avoidance, elevated maze plus paradigm and changes in acetylcholinesterase activity.
RESULTS:Treatment of young and old rats with the extract resulted in no significant difference in performance on the rota rod treadmill test/righting reflex time. Green tea extract significantly improved learning and memory in older rats, with increased retention latency to enter difference in passive avoidance test. In the elevated maze test, green tea treatment resulted in significantly more number of entries in the enclosed arm by the young and old rats. Decline in acetylcholinesterase activity was observed in the cerebrum of green tea treated old rats in comparison to the green tea treated young rats.
CONCLUSION:Green tea extract administration is effective in enhancing learning and memory in aged rats, and hence, may serve useful in reversing age-related deficits.
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【Effects of green tea extract on learning, memory, behavior and acetylcholinesterase activity in young and old male rats.].
【绿茶提取物对年轻和老年雄性大鼠学习，记忆，行为和乙酰胆碱酯酶活性的影响。】
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DOI：10.1016/j.bandc.2007.10.003文章类型：杂志文章
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目的：研究绿茶提取物对雄性和老年雄性Wistar大鼠年龄相关认知的影响。
方法：对成年和成年大鼠口服0.5％的绿茶提取物，持续8周，并通过被动回避，迷宫加范式和乙酰胆碱酯酶活性的变化进行评估。
结果：用提取物处理年轻和老龄大鼠，在旋转棒跑步机测试/扶正反射时间上的表现没有显着差异。绿茶提取物可显着改善老年大鼠的学习和记忆能力，并增加保留潜伏期，从而使被动回避测试产生差异。在高迷宫测试中，绿茶处理导致幼鼠和老鼠进入封闭臂的次数明显增加。与绿茶处理的幼鼠相比，绿茶处理的老鼠的大脑中乙酰胆碱酯酶活性下降。
结论：绿茶提取物给药可有效增强衰老大鼠的学习和记忆能力，因此可能有助于逆转与年龄有关的缺陷。
方法：对成年和成年大鼠口服0.5％的绿茶提取物，持续8周，并通过被动回避，迷宫加范式和乙酰胆碱酯酶活性的变化进行评估。
结果：用提取物处理年轻和老龄大鼠，在旋转棒跑步机测试/扶正反射时间上的表现没有显着差异。绿茶提取物可显着改善老年大鼠的学习和记忆能力，并增加保留潜伏期，从而使被动回避测试产生差异。在高迷宫测试中，绿茶处理导致幼鼠和老鼠进入封闭臂的次数明显增加。与绿茶处理的幼鼠相比，绿茶处理的老鼠的大脑中乙酰胆碱酯酶活性下降。
结论：绿茶提取物给药可有效增强衰老大鼠的学习和记忆能力，因此可能有助于逆转与年龄有关的缺陷。
