The advantages of Alloderm outweigh its disadvantages. This material provides a natural alternative to alloplastic materials in certain situations. Alloderm integrates into the patient's tissue, eliminating concerns associated with alloplastic material. Because it is of human origin, there is a remarkable lack of tissue reactivity after implantation. Volume persistence remains a concern. Because reports vary, the surgeon must determine the degree of persistence in his or her own hands and use larger pieces or multiple layers if necessary. Currently, Alloderm acellular human dermal tissue seems to be a successful modality for soft-tissue augmentation to improve various aesthetic and reconstructive deficiencies.