Gonorrhea is essentially out of control in many settings and high disease rates are coupled with the spread of multiresistant gonococci. Increases in quinolone resistance have followed loss of the penicillins and tetracyclines as useful treatments. Decreasing susceptibility to third-generation cephalosporins is also reported. Over-reliance on antibiotic treatment as a disease control measure in settings with high disease rates and poor control of antibiotic usage is a significant contributor to the antimicrobial resistance reported. Conversely, containment of resistance is more likely to be achieved when combined with disease control principles shown to be effective. However, until a higher priority is given to funding for sexually transmitted diseases, this prospect is unlikely to eventuate and the possibility of untreatable gonorrhea becomes more real.

译文

淋病在许多情况下基本上是无法控制的,高发病率与多耐药性淋球菌的传播有关。青霉素和四环素类药物丧失后,喹诺酮类药物耐药性增加,这是有用的治疗方法。还报道了对第三代头孢菌素的敏感性降低。在疾病发生率高且抗生素使用控制不佳的环境中,过度依赖抗生素治疗是一种疾病控制措施,是导致抗生素耐药性的重要原因。相反,当与已证明有效的疾病控制原则相结合时,更可能实现抗药性。但是,除非将更高的优先权用于性传播疾病的资助,否则这种前景不太可能实现,无法挽回的淋病的可能性变得更加现实。

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