OBJECTIVES:To evaluate health related quality of life (HRQOL) using the Medical Outcomes Study 8-items Short Form Health Survey (SF-8) questionnaire in Japanese patients with early prostate cancer. METHODS:A cross-sectional analysis was done in 457 patients with prostate cancer treated with radical prostatectomy, external beam radiotherapy, brachytherapy, androgen deprivation therapy, and watchful waiting or a combination these therapies. General HRQOL was measured using the Japanese version of the SF-8 questionnaire and disease-specific HRQOL was assessed using the Japanese version of the Extended Prostate Cancer Index Composite. RESULTS:The external beam radiotherapy group reported significantly lower values for the physical health component summary score (PCS) in comparison to the radical prostatectomy and brachytherapy groups (P < 0.05). In the analysis of both the PCS and the mental health component summary score (MCS) over time after treatment, higher scores with time were found in the radical prostatectomy group. No significant change over time after androgen deprivation therapy in the PCS was found. In contrast, the MCS was found to deteriorate in the early period, showing a significant increase over time. CONCLUSIONS:SF-8 in combination with the Extended Prostate Cancer Index Composite has shown to be a helpful tool in the HRQOL assessment of Japanese patients treated for localized prostate cancer.

译文

目的:使用医疗结果研究8项简式健康调查(SF-8)问卷对日本早期前列腺癌患者进行健康相关生活质量(HRQOL)评估。
方法:对457例前列腺癌患者进行横断面分析,这些患者接受了根治性前列腺切除术,外照射,放疗,近距离放射治疗,雄激素剥夺治疗以及警惕的等待或这些疗法的组合。普通HRQOL使用日文版SF-8问卷进行测量,而疾病特异性HRQOL使用日文版扩展前列腺癌指数复合材料进行评估。
结果:与放射根治性前列腺切除术和近距离放射治疗组相比,外束放射治疗组报告的身体健康成分摘要评分(PCS)值明显更低(P <0.05)。在分析治疗后随时间变化的PCS和精神健康成分总评分(MCS),在前列腺癌根治术组中发现随时间推移得分更高。在PCS中,雄激素剥夺治疗后未发现随时间的显着变化。相反,发现MCS在早期恶化,显示随时间的推移显着增加。
结论:SF-8与前列腺癌综合指数扩展结合已被证明是对日本人接受局部前列腺癌治疗的HRQOL评估的有用工具。

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