BACKGROUND:One of the critical problems in cancer management is local recurrence of disease. Between 20% and 30% of patients who undergo tumor resection surgery require reoperation due to incomplete excision. Currently, there are no validated methods for intraoperative tumor margin detection. In the present work, we demonstrate the potential use of gold nanoparticles (GNPs) as a novel contrast agent for photothermal molecular imaging of cancer. METHODS:Phantoms containing different concentrations of GNPs were irradiated with continuous-wave laser and measured with a thermal imaging camera which detected the temperature field of the irradiated phantoms. RESULTS:The results clearly demonstrate the ability to distinguish between cancerous cells specifically targeted with GNPs and normal cells. This technique, which allows highly sensitive discrimination between adjacent low GNP concentrations, will allow tumor margin detection while the temperature increases by only a few degrees Celsius (for GNPs in relevant biological concentrations). CONCLUSION:We expect this real-time intraoperative imaging technique to assist surgeons in determining clear tumor margins and to maximize the extent of tumor resection while sparing normal background tissue.

译文

背景:癌症治疗中的关键问题之一是疾病的局部复发。接受肿瘤切除手术的患者中有20%至30%由于切除不完全而需要再次手术。目前,尚无经验证的术中肿瘤边缘检测方法。在本工作中,我们证明了金纳米颗粒(GNP)作为癌症光热分子成像的新型造影剂的潜在用途。
方法:用连续波激光辐照含有不同浓度GNP的人体模型,并用热像仪测量,以检测所辐照人体模型的温度场。
结果:这些结果清楚地表明了区分GNPs特异性靶向癌细胞和正常细胞的能力。这项技术可以在相邻的低GNP浓度之间进行高度灵敏的区分,当温度仅升高几摄氏度时(对于相关生物浓度的GNP),就可以检测肿瘤边缘。
结论:我们希望这种实时术中成像技术能够帮助外科医生确定清楚的肿瘤切缘,并在保留正常背景组织的同时最大程度地扩大肿瘤切除范围。

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