BACKGROUND & AIMS:
Background:The diagnostic and prognostic role of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in heart failure is well established. However, additional factors may influence its concentration. One of them is obesity, which in general is accompanied by reduced NT-proBNP levels. However, specific data concerning metabolic syndrome (MS) are equivocal. The aim of the present study was to evaluate the association of NT-proBNP with estimated insulin resistance (eIR) in men with MS.
Methods:In 86 male patients with MS (78 of them hypertensive), blood pressure, anthropometric measures, NT-proBNP, creatinine, glucose, and insulin were assessed and eIR was calculated using homeostatic model assessment (HOMA-IR).
Results:Both eIR and age were independently associated with NT-proBNP concentrations (b = 0.2248, p=0.019; b = 0.0102, p=0.049, respectively). Blood pressure, anthropometric measures, and eGFR were not correlated with NT-proBNP. Patients without eIR had higher NT-proBNP than those with eIR (32.2 ± 26.4 vs 21.4 ± 25.4 pg/mL, p=0.014). The difference was even higher in the younger subgroup of patients reaching nearly 50%.
Conclusions:Insulin resistance and, to a lesser degree, age were associated with NT-proBNP levels in men with MS. In younger subjects with eIR, mean NT-proBNP level was lower than in corresponding healthy age males.
背景与目标:
背景:N末端前B型利钠尿肽(NT-proBNP)在心力衰竭中的诊断和预后作用已得到很好的确立。但是,其他因素可能会影响其浓度。其中之一是肥胖,其通常伴随着NT-proBNP水平的降低。但是,有关代谢综合征(MS)的具体数据是模棱两可的。本研究的目的是评估NT-proBNP与MS男性估计胰岛素抵抗(eIR)的相关性。
方法:对86例男性MS患者(其中78例为高血压患者)进行血压,人体测量,NT-proBNP,肌酐,葡萄糖和胰岛素评估,并使用稳态模型评估(HOMA-IR)计算eIR。
结果:eIR和年龄均与NT-proBNP浓度独立相关(b = 0.2248,p = 0.019; b = 0.0102,p = 0.049)。血压,人体测量学指标和eGFR与NT-proBNP不相关。没有eIR的患者的NT-proBNP高于有eIR的患者(32.2±±26.4 vs 21.4±±25.4μpg/ mL,p = 0.014)。在年轻的患者亚组中,差异甚至更高,达到近50%。
结论:MS男性中NT-proBNP水平与胰岛素抵抗和较小的年龄有关。在较年轻的eIR患者中,平均NT-proBNP水平低于相应健康年龄的男性。