Phytochemical investigation on the 70% ethanol extract of the leaves of Alstonia mairei resulted in the isolation of three new monoterpenoid indole alkaloids, alstomairines A-C (1-3), along with one known compound, alpneumine A (4). Structural elucidation of all the compounds was accomplished by spectral methods such as 1D and 2D NMR, IR, UV, and HRESIMS. The isolated compounds were tested in vitro for cytotoxic activities against four osteosarcoma cell lines. Consequently, alkaloids 2 and 3 exhibited cytotoxic activities for all tested tumor cell lines with IC50 values from 9.2 to 13.0 μM.

译文

对Alstonia mairei叶片的70% 乙醇提取物的植物化学研究导致隔离出三种新的单萜类吲哚生物碱alstomaines a-c (1-3) 以及一种已知化合物alpneumines A (4)。所有化合物的结构阐明均通过光谱方法 (例如1D和2D NMR,IR,UV和hresms) 完成。在体外测试了分离出的化合物对四种骨肉瘤细胞系的细胞毒性活性。因此,生物碱2和3对所有测试的肿瘤细胞系表现出细胞毒性活性,IC50值为9.2至13.0微米。

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