Two new quinolizidine-based alkaloids (2 and 12), along with ten known ones (1, 3-11) were isolated from the roots of S. tonkinensis. Their structures were determined by spectroscopic data (including NMR, MS, IR, and UV), X-ray single crystal diffraction, electronic circular dichroism analyses (ECD), and comparing with related literatures. Compounds 1, 3-12 at non-toxic concentrations exhibited potent anti-inflammatory activities according to in vitro and in vivo anti-inflammatory tests. Among them, (-)-anagyrine (4), sophocarpine (8), 14β-hydroxymatrine (10), and 7β-sophoramine (12) showed more potent in vitro anti-inflammatory activities, and 5α,14β-dihydroxymatrine (2), (-)-anagyrine (4), sophocarpine (8), and 5α-hydroxymatrine (9) exhibited better in vivo anti-inflammatory effects.

译文

从tonkinensis的根中分离出两种新的基于喹啉嗪的生物碱 (2和12) 以及十种已知的生物碱 (1,3-11)。通过光谱数据 (包括NMR,MS,IR和UV),x射线单晶衍射,电子圆二色性分析 (ECD) 确定了它们的结构,并与相关文献进行了比较。根据体外和体内抗炎试验,无毒浓度的化合物1、3-12表现出有效的抗炎活性。其中,(-)-anagyrine (4),槐果碱 (8),14β-羟基苦参碱 (10) 和7β-槐胺 (12) 表现出更有效的体外抗炎活性,而5α,14β-二羟基苦参碱 (2),(-)-anagyrine (4),槐果碱 (8) 和5α-羟基苦参碱 (9) 表现出更好的体内抗炎作用。

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