Inhibition of repair of sublethal and potentially lethal damage was observed in respiratory-deficient mutants of yeast during fractionated X-irradiation in the presence of equimolar concentrations of 2-deoxy-D-glucose and glucose in the growth medium. In the wild-type cells, on the other hand, an enhancement of repair of the potentially lethal damage was obtained under similar conditions. These results suggest, by analogy, that in higher organisms also, 2-deoxy-D-glucose may differentially inhibit the repair of radiation damage in hypoxic tumor cells while enhancement of repair processes could be expected in normal tissues.

译文

:在生长培养基中存在等摩尔浓度的2-脱氧-D-葡萄糖和葡萄糖的情况下,在分级X射线辐照期间,在酵母的呼吸不足突变体中观察到了对亚致死和潜在致死性损伤的修复的抑制作用。另一方面,在野生型细胞中,在类似条件下获得了对潜在致死性损伤的修复增强作用。类似地,这些结果表明,在高等生物中,2-脱氧-D-葡萄糖也可以差异地抑制缺氧肿瘤细胞中辐射损伤的修复,而在正常组织中有望增强修复过程。

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