OBJECTIVE:According to recent surveys, outpatient antibiotic prescribing in Germany has been comparatively low among European countries. We assessed regional variation in outpatient antibiotic use within Germany both for overall use as well as for specific antibiotic drug classes. METHODS:Prescription data for the year 2003 covering approximately 90% of the total population were analysed using the ATC/WHO defined daily dose (DDD) methodology. Data were expressed in DDD per 1,000 persons covered by the insurance and day (DID). RESULTS:Outpatient antibiotic prescribing in 2003 was 13.6 DID and ranged between 9.2 and 17.9 DID in the different regions examined. Low consumption regions were eastern and southern states. High consumption areas were in the west near the French and Belgian border. This regional prescribing pattern was similar for children and adults. Penicillins were the most frequent prescribed drugs, but their use density showed a relatively large regional variation (factor 3.5), with relatively low prescription frequency in the eastern states. In almost all regions quinolones were used more often than trimethoprim-sulfamethoxazole. CONCLUSION:The regional variation in recent outpatient antibiotic prescribing in Germany is substantial. The relatively high antibiotic use in the western part of the country is remarkable, remains unexplained and requires further study.

译文

目的:根据最近的调查,德国的门诊抗生素处方在欧洲国家中相对较低。我们评估了德国境内整体使用以及特定抗生素类药物在门诊使用抗生素方面的地区差异。
方法:使用ATC / WHO规定的日剂量(DDD)方法分析了2003年的处方数据,涵盖了约90%的总人口。数据以DDD表示,每千人保险和日数(DID)。
结果:2003年门诊抗生素处方的DID为13.6 DID,在所检查的不同区域范围为9.2-17.9 DID。低耗地区是东部和南部各州。高消费地区位于法国和比利时边境附近的西部。对于儿童和成人,这种区域性处方模式是相似的。青霉素是最常用的处方药,但其使用密度显示出较大的区域差异(系数3.5),而东部各州的处方频率相对较低。在几乎所有地区,喹诺酮类药物的使用都比甲氧苄氨嘧啶-磺胺甲基恶唑要多。
结论:德国近期门诊抗生素处方的地区差异很大。该国西部地区的抗生素使用量相对较高,仍然无法解释,需要进一步研究。

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