Mast cells are known to be effector cells in various inflammatory reactions, but their role in appendicitis is unclear. The present study was undertaken to investigate the extent of mast cell involvement in appendicitis and evaluate their possible role. A total of 150 appendices including normal and inflamed appendices, were assessed for their histological changes and density of neutrophil, lymphocyte and eosinophil infiltration. The mast cells were counted in 1% toluidine blue-stained sections. It was found that eosinophil counts in all the layers were significantly low in normal appendices (P<0.01) and in chronic appendicitis (P<0.1) as compared to acute appendicitis. Mast cell counts were lowest in normal appendices, significantly higher in acute appendicitis (P<0.01) and highest in chronic appendicitis (P<0.001). Obstruction due to faecoliths or parasites were seen in only 20.1% and 2.1% of the inflamed appendices respectively. Hence a Type I hypersensitivity reaction with release of mediators by mast cells might be another triggering factor for the sequence of events leading to appendicitis.

译文

:已知肥大细胞是各种炎症反应中的效应细胞,但它们在阑尾炎中的作用尚不清楚。本研究旨在研究肥大细胞参与阑尾炎的程度并评估其可能的作用。共评估了150个阑尾,包括正常和发炎的阑尾的组织学变化以及中性粒细胞,淋巴细胞和嗜酸性粒细胞浸润的密度。肥大细胞在1%甲苯胺蓝染色的切片中计数。发现与急性阑尾炎相比,正常阑尾(P <0.01)和慢性阑尾炎(P <0.1)所有层的嗜酸性粒细胞计数均显着较低。正常阑尾中的肥大细胞计数最低,急性阑尾炎中的肥大细胞计数显着更高(P <0.01),而慢性阑尾炎中的肥大细胞计数最高(P <0.001)。分别在发炎的阑尾中仅见20.1%和2.1%的因粪便或寄生虫引起的阻塞。因此,肥大细胞释放介体的I型超敏反应可能是导致阑尾炎的一系列事件的另一个触发因素。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录