Owing to its interaction with alcohol, folate has been suggested to be a potential factor for many types of cancer. The impact of these factors on the risk of breast cancer among Asian populations has not been fully examined, however, particularly with respect to receptor status. We carried out a case-control study in premenopausal and postmenopausal Japanese women, including 1754 breast cancer patients and 3508 noncancer controls. We determined the association between self-reported alcohol drinking, dietary folate intake, and the risk of breast cancer. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated using logistic models adjusted for potential confounders. Alcohol consumption was associated with the risk of breast cancer, with the OR for a drinker consuming 23 g or more per day relative to a nondrinker of 1.39 (95% CI: 1.07-1.80). A significant inverse association was observed between folate intake and overall risk of breast cancer, with an OR of 0.79 (95% CI: 0.68-0.93; Ptrend=0.004) for the highest tertile relative to the lowest. The OR of a drinker consuming 23 g or more per day relative to a nondrinker with a low folate intake was 1.58 (95% CI: 1.06-2.33). However, a significantly increased risk was not observed in tertile 2 and tertile 3 folate in taker with any amount of alcohol consumption. Higher folate intake decreases the risk of breast cancer among Japanese, whereas alcohol intake increases the risk. These two factors interact with each other, and the excess risk of breast cancer with alcohol consumption might be attenuated by increasing the intake of folate. In addition, the effects of folate/alcohol may vary according to the tumor subtype.

译文

由于叶酸与酒精的相互作用,叶酸被认为是许多类型癌症的潜在因素。然而,这些因素对亚洲人群乳腺癌风险的影响尚未得到充分研究,特别是在受体状态方面。我们对绝经前和绝经后的日本女性进行了病例对照研究,包括1754例乳腺癌患者和3508例非癌症对照。我们确定了自我报告的饮酒,饮食中叶酸摄入量与乳腺癌风险之间的关联。使用校正了潜在混杂因素的逻辑模型来估计具有95% 置信区间 (CIs) 的优势比 (or)。饮酒与患乳腺癌的风险相关,饮酒者的OR每天消耗23g或更多,相对于不饮酒的1.39 (95% CI: 1.07-1.80)。观察到叶酸摄入量与乳腺癌的总体风险之间存在显着的负相关,相对于最低的,最高的三分位数的OR为0.79 (95% CI: 0.68-0.93; Ptrend = 0.004)。1.58了相对于叶酸摄入量低的非饮酒者每天摄入23 g或更多的饮酒者的OR (95% CI: 1.06-2.33)。然而,在摄入任何量的酒精的情况下,在摄入的2号和3号叶酸中没有观察到明显增加的风险。较高的叶酸摄入量降低了日本人患乳腺癌的风险,而饮酒则增加了患乳腺癌的风险。这两个因素相互作用,饮酒可能会通过增加叶酸的摄入量来降低乳腺癌的超额风险。此外,叶酸/酒精的作用可能因肿瘤亚型而异。

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