We have previously demonstrated that gonadectomy either prior to (early) or after (late) puberty elevated ethanol consumption in males to levels similar to intact adult females-effects that were attenuated by testosterone replacement. To assess whether alterations in the aversive effects of ethanol might contribute to gonadectomy-associated increases in ethanol intake in males, the present study examined the impact of gonadectomy on conditioned taste aversions (CTA) to ethanol in male and female Sprague-Dawley rats. Animals were gonadectomized, received sham surgery (SH) or non-manipulated (NM) on postnatal (P) day 23 (early) or 67 (late) and tested for CTA to ethanol in adulthood. Water-deprived rats were given 1 hr access every-other-day to 10% sucrose followed by an injection of ethanol (0, 1g/kg) for 5 test sessions. Test data were analyzed to determine the first day significant aversions emerged in each ethanol group (i.e., sucrose intakes significantly less than their saline-injected counterparts). Early gonadectomized males acquired the CTA more rapidly than did early SH and NM males (day 1 vs 3 and 4 respectively), whereas a gonadectomy-associated enhancement in ethanol CTA was not evident in late males. Among females, gonadectomy had little impact on ethanol-induced CTA, with females in all groups showing an aversion by the first or second day, regardless of surgery age. These data suggest that previously observed elevations in ethanol intake induced by either pre- or post-pubertal gonadectomy in males are not related simply to gonadectomy-induced alterations in the aversive effects of ethanol indexed via CTA.

译文

:我们以前已经证明,在青春期之前(早期)或青春期之后(晚期)进行性腺切除术会使男性的乙醇消耗量增加到与完整的成年女性相同的水平,这种作用会因睾丸激素的替代而减弱。为了评估乙醇的厌恶作用改变是否可能与男性进行性腺切除术相关的乙醇摄入量增加有关,本研究检查了性腺切除术对雄性和雌性Sprague-Dawley大鼠对乙醇的条件性味觉厌恶(CTA)的影响。在出生后(P)第23天(早期)或67(后期)对动物进行性腺切除术,进行假手术(SH)或不进行操作(NM),并在成年期测试其对乙醇的CTA。每隔一天给缺水的大鼠1小时使用10%的蔗糖,然后注射乙醇(0,1g / kg)进行5次测试。分析测试数据以确定每个乙醇组在第一天就出现了明显的厌恶感(即蔗糖摄入量明显少于其注射生理盐水的对应物)。早期进行过性腺切除的男性比早期SH和NM男性(分别为第1天,第3天和第4天)更快地获得了CTA,而在晚期男性中,与性腺切除术相关的乙醇CTA的增强并不明显。在女性中,性腺切除术对乙醇诱导的CTA几乎没有影响,所有组中的女性在第一天或第二天都表现出厌恶感,无论手术年龄如何。这些数据表明,先前观察到的男性青春期前或青春期后性腺切除术诱导的乙醇摄入量增加与单纯性腺切除术诱导的通过CTA索引的乙醇的厌恶作用改变无关。

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